Lisbon Airport Airlines
| Airlines | Destinations |
|---|---|
| Aegean Airlines | Athens |
| Aer Lingus | Dublin |
| Aeroflot | Moscow–Sheremetyevo |
| Air Canada | Toronto–Pearson Seasonal: Montréal–Trudeau |
| Air Europa | Madrid |
| Air France | Paris–Charles de Gaulle |
| Air Malta | Malta |
| Air Moldova | Chişinău |
| Air Transat | Montréal–Trudeau (resumes 15 September 2021), Toronto–Pearson (resumes 02 November 2021) |
| airBaltic | Riga |
| American Airlines | Seasonal: Philadelphia (resumes 27 March 2022) |
| Azores Airlines | Boston, Horta, Pico Island, Ponta Delgada, Praia, Santa Maria, Terceira, Toronto–Pearson |
| Azul Brazilian Airlines | Campinas |
| Beijing Capital Airlines | Beijing–Daxing, Xi’an |
| Binter Canarias | Gran Canaria, Tenerife–North |
| Blue Air | Bucharest |
| British Airways | London–Heathrow |
| Brussels Airlines | Brussels |
| Bulgaria Air | Seasonal: Sofia (suspended) |
| Cabo Verde Airlines | Praia, Sal |
| Delta Air Lines | New York–JFK Seasonal: Boston |
| easyJet | Amsterdam, Basel/Mulhouse, Berlin, Bordeaux, Bristol, Edinburgh, Funchal, Geneva, London–Gatwick, London–Luton, Luxembourg, Lyon, Madrid, Manchester, Milan–Malpensa, Nantes, Nice, Paris–Charles de Gaulle |
| El Al | Tel Aviv |
| Emirates | Dubai–International |
| euroAtlantic Airways | Bissau |
| Eurowings | Cologne/Bonn, Düsseldorf, Stuttgart |
| Finnair | Helsinki |
| FlyOne | Chişinău |
| HiSky | Chișinău (begins 11 August 2021), Cluj-Napoca |
| Iberia | Madrid |
| Jet2.com | Birmingham (begins 30 September 2021), Manchester (begins 03 September 2021) |
| KLM | Amsterdam |
| LATAM | São Paulo–Guarulhos |
| Lufthansa | Frankfurt, Munich |
| Luxair | Luxembourg |
| Norwegian Air Shuttle | Copenhagen, Stockholm–Arlanda Seasonal: Oslo (resumes 19 August 2021) |
| Orbest | Seasonal: Cancún, Punta Cana, Varadero |
| Royal Air Maroc | Casablanca |
| Ryanair | Agadir (begins 31 October 2021), Alghero (begins 1 November 2021),Alicante (begins 2 November 2021), Barcelona (begins 31 October 2021), Bari (begins 31 October 2021), Beauvais, Bergamo, Berlin, Billund (begins 1 November 2021),Birmingham (begins 1 November 2021), Bologna, Bordeaux, Bournemouth (begins 2 November 2021), Brest (begins 31 October 2021), Brussels, Budapest, Charleroi, Cologne/Bonn, Dublin, Edinburgh, Eindhoven, Fez (begins 31 October 2021),Karlsruhe/Baden-Baden (begins 3 November 2021), Krakow, Lanzarote (begins 2 November 2021), London–Stansted, Luxembourg, Madrid (begins 31 October 2021), Málaga, Malta (begins 2 November 2021), Manchester, Marrakesh (begins 1 November 2021),Marseille, Memmingen, Naples, Oujda (begins 31 October 2021), Palermo (begins 1 November 2021), Perpignan (begins 1 November 2021), Ponta Delgada, Rome–Ciampino, Seville, Tenerife-South (begins 2 November 2021), Terceira, Toulouse, Tours (begins 31 October 2021), Valencia, Vienna, Warsaw–Modlin, Wrocław (begins 31 October 2021), Zaragoza Seasonal: Pisa |
| Scandinavian Airlines | Seasonal: Copenhagen, Stockholm–Arlanda |
| SkyUp | Kyiv–Boryspil |
| STP Airways | São Tomé |
| Swiss International Air Lines | Geneva, Zürich |
| TAAG Angola Airlines | Luanda |
| TAP Air Portugal | Abidjan, Accra, Agadir, Alicante, Amsterdam, Banjul, Barcelona, Belém, Belo Horizonte–Confins, Berlin, Bilbao, Bissau, Boa Vista, Bologna, Bordeaux, Boston, Brasília, Brussels, Budapest, Cancún, Cape Town (begins 31 October 2021), Caracas, Casablanca, Chicago–O’Hare, Conakry, Copenhagen, Dakar–Diass, Dublin, Düsseldorf, Faro, Florence, Fortaleza, Frankfurt, Fuerteventura, Funchal, Geneva, Gran Canaria, Hamburg, Helsinki, London–Gatwick, London–Heathrow, Luanda, Luxembourg, Lyon, Maceió, Madrid, Málaga, Manchester, Maputo, Marrakech, Marseille, Miami, Milan–Malpensa, Monastir, Montréal–Trudeau, Moscow–Domodedovo, Munich, Nantes, Naples, Natal, Newark, New York–JFK, Nice, Oslo, Paris–Orly, Ponta Delgada, Porto, Porto Alegre, Porto Santo, Prague, Praia, Recife, Rio de Janeiro–Galeão, Rome–Fiumicino, Sal, Salvador da Bahia, San Francisco, Santiago de Compostela (resumes 27 March 2022), São Paulo–Guarulhos, São Tomé, São Vicente, Seville, Stockholm–Arlanda, Tel Aviv, Tenerife–South, Terceira, Toronto–Pearson, Toulouse, Valencia, Venice, Vienna, Warsaw–Chopin, Washington–Dulles, Zagreb, Zürich Seasonal: Ibiza, Oujda, Punta Cana (resumes 11 December 2021), Tangier |
| Transavia | Amsterdam, Eindhoven, Lyon, Montpellier, Nantes, Paris–Orly, Rotterdam/The Hague |
| Turkish Airlines | Istanbul |
| United Airlines | Newark Seasonal: Washington–Dulles |
| Vueling | Amsterdam, Barcelona, Bilbao, Ibiza, Palma de Mallorca, Paris–Orly, Tenerife–North, Valencia |
| Wizz Air | Bucharest, Budapest, Dortmund, Kyiv–Zhuliany, London–Luton, Lviv, Milan–Malpensa, Sofia, Vienna, Warsaw–Chopin |